DVD-445 manufacturers
- DVD-445
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- $69.00
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2026-07-14
- CAS:2375846-41-4
- Purity:
- Supply Ability: 10g
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| | DVD-445 Basic information |
| Product Name: | DVD-445 | | Synonyms: | DVD-445;2-Butenoic acid, 4-(4-fluorophenyl)-4-oxo-, 2-[[2-[(1,1-dimethylethyl)amino]-1-(4-fluorophenyl)-2-oxoethyl]methylamino]ethyl ester, (2E)- | | CAS: | 2375846-41-4 | | MF: | C25H28F2N2O4 | | MW: | 458.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2375846-41-4.mol |  |
| | DVD-445 Chemical Properties |
| Boiling point | 597.1±50.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C) | | pka | 15.06±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | DVD-445 Usage And Synthesis |
| Uses | DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1]. | | References | [1] Jovanovi M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580. DOI:10.1016/j.ejmech.2019.111580 |
| | DVD-445 Preparation Products And Raw materials |
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