| Company Name: |
Biolab Reagents |
| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
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| | Disitamab Basic information |
| Product Name: | Disitamab | | Synonyms: | Disitamab;Research Grade Disitamab (DHC09603);Research Grade Disitamab;Disitamab (anti-ERBB2);Immunoglobulin G1, anti-(human tyrosine kinase receptor ErbB2) (human-Mus musculus monoclonal RC48-0 γ1-chain), disulfide with human-Mus musculus monoclonal RC48-0 κ-chain, dimer (ACI) | | CAS: | 2185868-98-6 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Disitamab Structure]() |
| | Disitamab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Disitamab Usage And Synthesis |
| Uses | Disitamab (RC48-0) is a humanized monoclonal antibody targeting HER2. Disitamab can be used in the synthesis of antibody-drug conjugates (ADCs), Disitamab vedotin (Disitamab vedotin (HY-P9985))[1]. | | in vivo | Disitamab (27 mg/kg; i.v.; once; 5 mL/kg) shows no significant toxicity in monkeys[1]. | | IC 50 | HER2 | | References | [1] Jiang J, et al. Preclinical safety profile of disitamab vedotin：a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37. DOI:10.1016/j.toxlet.2019.12.027 |
| | Disitamab Preparation Products And Raw materials |
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