L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
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L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- manufacturers
L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;VH 032 amide-PEG1-acid;3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid;VH032-C1-PEG1-COOH;(S,R,S)-AHPC-CO-PEG1-C2-acid;(S,R,S)-AHPC-CO-PEG1-C2-acid
CAS:2172820-07-2
MF:C28H38N4O7S
MW:574.69
EINECS:
Product Categories:
Mol File:2172820-07-2.mol
L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 889.8±65.0 °C(Predicted)
density 1.290±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka4.28±0.10(Predicted)
form powder or crystals
color white to light yellow
InChIKeyHVPZHRHEHKZOOJ-TYBLODHISA-N
SMILESC([C@@H](NC(CCOCCC(O)=O)=O)[C@@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
DescriptionVH 032 amide-PEG1-acid is a VHL ligand with PEG linker and terminal acid for onward chemistry.
UsesVH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g.,E3 ligase ligands)[1].
storageStore at -20°C
References[1] Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WIPO(PCT). WO2018106870A1. 2018-06-14.
L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Tag:L-Prolinamide, N-[3-(2-carboxyethoxy)-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2172820-07-2) Related Product Information
Protac linker 5 VH 032-linker 8 E3 ligase Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 8 E3 ligase Ligand-Linker Conjugates 5 Free Base (S,R,S)-AHPC-C10-NH2 dihydrochloride