5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester
| 中文名称 | 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester |
|---|---|
| 中文同义词 | 化合物 T24503;化合物 MS438;6-甲基-2-氧代-4-[4-(三氟甲基)苯基]-1,2,3,4-四氢嘧啶-5-甲酸苄酯 |
| 英文名称 | 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester |
| 英文同义词 | 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester;MS438;Benzyl6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate |
| CAS号 | 512840-45-8 |
| 分子式 | C20H17F3N2O3 |
| 分子量 | 390.36 |
| EINECS号 | |
| 相关类别 | 制剂-激动剂 |
| Mol文件 | 512840-45-8.mol |
| 结构式 | ![5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester 结构式](CAS/20210305/GIF/512840-45-8.gif) |
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester 性质
| 沸点 | 481.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.299±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 10.85±0.70(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, phenylmethyl ester 用途与合成方法
MS438 是一种有效的促甲状腺素受体 (TSHR) 激动剂，其EC50 为 53 nM。MS438 与 TSHR 的蛇形部分结合。MS438 诱导小鼠 T4 分泌。