Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- manufacturers
- 84-B10
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2026-07-17
- CAS:698346-43-9
- Purity:
- Supply Ability: 10g
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| | Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- Basic information |
| | Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- Chemical Properties |
| Boiling point | 614.1±55.0 °C(Predicted) | | density | 1.329±0.06 g/cm3(Predicted) | | solubility | DMSO: Sparingly soluble: 1-10 mg/ml | | form | Solid | | pka | 4.46±0.10(Predicted) | | color | White to off-white |
| | Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- Usage And Synthesis |
| Uses | 84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1]. | | in vivo | 84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice[1]. | Animal Model: | Male C57BL/6 mice with acute kidney injury[1] | | Dosage: | 5, 10, and 15 mg/kg | | Administration: | intraperitoneal injection | | Result: | Decreased the sCr and BUN levels of cisplatin-exposed mice.
Attenuated renal tubules morphological abnormalities in a dose-dependent manner.
Decreased NGAL and KIM-1 levels in a dose-dependent manner.
Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.
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| | References | [1] Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98. DOI:10.1016/j.freeradbiomed.2022.11.029 |
| | Benzenepropanoic acid, β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]- Preparation Products And Raw materials |
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