84-B10 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: 84-B10 | CAS No.: 698346-43-9 |
| Supply Ability: 10g | Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | 84-B10 |
| Description | 84-B10 protects against cisplatin-induced acute kidney injury, reversing lipid peroxidation accumulation and downregulation of key ferroptosis inhibitors, inhibiting mitochondrial damage and mtROS production, and restoring superoxide dismutase to reduce cisplatin-induced kidney damage. |
| In vitro | 84-B10 (10-100 μM,2 h) inhibited cisplatin induced iron death in renal tubular epithelial cells in a dose-dependent manner. Treatment with 84-B10 (40 μM, 2 hours) restored cisplatin induced mitochondrial structural damage and dysfunction. 84-B10 (40 μM, 2 hours) mitigated MTROS-induced oxidative stress in cisplatin-induced AKI. 84-B10 (40 μM, 2 hours) alleviates cisplatin induced epithelial cell damage by eliminating mtROS and restoring mitochondrial homeostasis [1]. |
| In vivo | 84-B10 plays a protective role in cisplatin induced acute kidney injury, but has no tumor-promoting effect. [1] |
| Storage | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.22 mM), Sonication is recommended. H2O : < 0.1 mg/mL (insoluble) DMSO : 80 mg/mL (168.98 mM), Sonication is recommended. |
| Inhibitors Related | TBHQ | Rosiglitazone | α-Vitamin E | L-Glutamic acid | Sorafenib | Curcumin | Gallic Acid Monohydrate | Artemisinin | L-Cystine | L-Glutamine | L-Glutamic acid monosodium salt | Cisplatin |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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