Pyrazinecarboxamide, 3-amino- (7CI,9CI) manufacturers
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| | Pyrazinecarboxamide, 3-amino- (7CI,9CI) Basic information |
| Product Name: | Pyrazinecarboxamide, 3-amino- (7CI,9CI) | | Synonyms: | Pyrazinecarboxamide, 3-amino- (7CI,9CI);3-Amino-pyrazine-2-carboxylic acid amide;2-Pyrazinecarboxamide, 3-amino-;Aminopyrazine carboxamide;Pyrazinecarboxamide, 3-amino;3-amino-2-pyrazinecarboxamide | | CAS: | 32587-10-3 | | MF: | C5H6N4O | | MW: | 138.13 | | EINECS: | | | Product Categories: | AMIDE | | Mol File: | 32587-10-3.mol |  |
| | Pyrazinecarboxamide, 3-amino- (7CI,9CI) Chemical Properties |
| Melting point | 239.3 °C | | Boiling point | 375.8±37.0 °C(Predicted) | | density | 1.426±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | form | Solid | | pka | 13.68±0.50(Predicted) | | Appearance | Light brown to brown Solid | | CAS DataBase Reference | 32587-10-3 |
| | Pyrazinecarboxamide, 3-amino- (7CI,9CI) Usage And Synthesis |
| Synthesis Reference(s) | Journal of the American Chemical Society, 81, p. 2472, 1959 DOI: 10.1021/ja01519a047 | | Synthesis | Example 2 Synthesis of 3-aminopyrazine-2-carboxamide (Intermediate 1): methyl 3-aminopyrazine-2-carboxylate (5.0 g, 33 mmol) was dissolved in concentrated ammonium hydroxide solution (30 mL), heated to 60°C and kept for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitated solid was collected by filtration. The solid was washed well with water and ether in turn to afford the title compound 3-aminopyrazine-2-carboxamide as a brown solid (3.7 g, 82% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 8.19 (d, J = 2.4 Hz, 1H), 8.07 (br s, 2H), 7.80 (d, J = 2.4 Hz, 1H), 7.59 (br s, 2H). Mass spectrum (ES+): m/z 139 ([M + H]+). | | References | [1] Journal of Heterocyclic Chemistry, 2012, vol. 49, # 4, p. 865 - 872
[2] Patent: CN106699759, 2017, A. Location in patent: Paragraph 0050; 0051; 0052
[3] Patent: US2007/259876, 2007, A1. Location in patent: Page/Page column 17
[4] Journal of the American Chemical Society, 1945, vol. 67, p. 1711
[5] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 13 |
| | Pyrazinecarboxamide, 3-amino- (7CI,9CI) Preparation Products And Raw materials |
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