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| | (S,R,S)-Ahpc-C2-PEG4-N3 Basic information |
| Product Name: | (S,R,S)-Ahpc-C2-PEG4-N3 | | Synonyms: | (2S,4R)-1-((S)-1-Azido-17-(tert-butyl)-15-oxo-3,6,9,12-tetraoxa-16-azaoctadecan-18-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(S,R,S)-Ahpc-C2-PEG4-N3 | | CAS: | 2597167-24-1 | | MF: | C33H49N7O8S | | MW: | 703.85 | | EINECS: | | | Product Categories: | | | Mol File: | 2597167-24-1.mol |  |
| | (S,R,S)-Ahpc-C2-PEG4-N3 Chemical Properties |
| | (S,R,S)-Ahpc-C2-PEG4-N3 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4 (HY-130647). vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1]. (S,R,S)-AHPC-C2-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | VHL | | References | [1] Wang S, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2 |
| | (S,R,S)-Ahpc-C2-PEG4-N3 Preparation Products And Raw materials |
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