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| | Eflornithine hydrochloride hydrate Basic information |
| | Eflornithine hydrochloride hydrate Chemical Properties |
| Melting point | >210°C (dec.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in Water (up to 25 mg/ml). | | form | White powder | | color | White | | Water Solubility | water: 1mg/mL
methanol: 25mg/mL | | Merck | 14,3522 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2 | | InChIKey | FJPAMFNRCFEGSD-UHFFFAOYSA-N | | SMILES | C(N)(C(=O)O)(C(F)F)CCCN.Cl.O | | CAS DataBase Reference | 96020-91-6 |
| WGK Germany | WGK 3 | | RTECS | RM2981900 | | HS Code | 2922493800 | | Storage Class | 11 - Combustible Solids |
| | Eflornithine hydrochloride hydrate Usage And Synthesis |
| Description | Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1Induces apoptosis in a variety of cells.2Difluoromethylornithine HCl displays cancer chemopreventive activity.3Cell permeable. Active in vivo. | | Chemical Properties | White Solid | | Uses | Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism. | | Definition | ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine. | | Brand name | Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica). | | General Description | A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro. | | Biochem/physiol Actions | Primary TargetODC | | References | [1] VERMA A K. Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.[J]. Basic life sciences, 1990, 52: 195-204. DOI:10.1007/978-1-4615-9561-8\_16
[2] Y TAKAHASHI K N M Mai. alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model.[J]. International Journal of Cancer, 2000, 85 2: 243-247.
[3] F L MEYSKENS E W G. Development of difluoromethylornithine (DFMO) as a chemoprevention agent.[J]. Clinical Cancer Research, 1999, 5 5: 945-951. |
| | Eflornithine hydrochloride hydrate Preparation Products And Raw materials |
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