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apogossypol

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apogossypol manufacturers

  • (+)-Apogossypol
  • (+)-Apogossypol pictures
  • $3100.00
  • 2026-04-21
  • CAS:66389-74-0
  • Purity:
  • Supply Ability: 10g
  • (+)-Apogossypol
  • (+)-Apogossypol pictures
  • $3100.00
  • 2025-08-22
  • CAS:66389-74-0
  • Purity:
  • Supply Ability: 10g
  • apogossypol
  • apogossypol pictures
  • 2025-04-04
  • CAS:66389-74-0
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 1Ton
apogossypol Basic information
Product Name:apogossypol
Synonyms:apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;NSC736630;APOGOSSYPOL;NSC736630;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol;(+)-APOGOSSYPOL;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;(+)Apogossypol,(+) Apogossypol
CAS:66389-74-0
MF:C28H30O6
MW:462.53
EINECS:
Product Categories:
Mol File:66389-74-0.mol
apogossypol Structure
apogossypol Chemical Properties
Melting point 118-123 °C
Boiling point 673.3±50.0 °C(Predicted)
density 1.335±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility >16.2mg/mL in DMSO with gentle warming
form Powder
pka8.03±0.50(Predicted)
Safety Information
MSDS Information
apogossypol Usage And Synthesis
Uses(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively.
Biological Activity(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitroIn agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivoDue to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
target

Mcl-1

< span> 2.6 μM (EC 50 )

Bcl-2

2.8 μM (EC 50 )

Bcl-xL

3.69 μM (EC 50 )

IC 50Mcl-1: 2.6 μM (EC50); Bcl-2: 2.8 μM (EC50); Bcl-xL: 3.69 μM (EC50)
References[1] Wei J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr;8(4):904-13. DOI:10.1158/1535-7163.MCT-08-1050
[2] Zhan W, et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Mol Med Rep. 2015 Jun;11(6):4142-8. DOI:10.3892/mmr.2015.3326
apogossypol Preparation Products And Raw materials
Tag:apogossypol(66389-74-0) Related Product Information
[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-diMethyl-5,5'-bis(1-Methylethyl)- (S)-(-)-5,5',6,6'-Tetramethyl-3,3'-di-tert-butyl-1,1'-biphenyl-2,2'-diol Gossypol acetic acid (S)-Gossypol (acetic acid) apogossypol AT-101