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(S)-Gossypol (acetic acid)

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(S)-Gossypol (acetic acid) manufacturers
(S)-Gossypol (acetic acid) Basic information
Product Name:(S)-Gossypol (acetic acid)
Synonyms:(S)-Gossypol (acetic acid)
CAS:1189561-66-7
MF:C32H34O10
MW:578.61
EINECS:
Product Categories:
Mol File:1189561-66-7.mol
(S)-Gossypol (acetic acid) Structure
(S)-Gossypol (acetic acid) Chemical Properties
storage temp. Store at -20°C, protect from light, stored under nitrogen
solubility DMSO: 50 mg/mL (86.41 mM); Water: < 0.1 mg/mL (insoluble)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
(S)-Gossypol (acetic acid) Usage And Synthesis
Uses(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
IC 50Bcl-2; Bcl-xL
References[1] Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. DOI:10.1158/1078-0432.CCR-04-0551
(S)-Gossypol (acetic acid) Preparation Products And Raw materials
Preparation Products[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)--->gossypolone
Tag:(S)-Gossypol (acetic acid)(1189561-66-7) Related Product Information
Gossypol-acetic acid GOSSYPOL AT-101 [2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Gossypol acetic acid (S)-Gossypol (acetic acid)