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| | 9H-Purin-6-amine, 9-(2-deoxy-4-C-ethynyl-2-fluoro-β-D-arabinofuranosyl)-2-fluoro- Basic information |
| | 9H-Purin-6-amine, 9-(2-deoxy-4-C-ethynyl-2-fluoro-β-D-arabinofuranosyl)-2-fluoro- Chemical Properties |
| Boiling point | 670.7±65.0 °C(Predicted) | | density | 1.79±0.1 g/cm3(Predicted) | | pka | 11.92±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | 9H-Purin-6-amine, 9-(2-deoxy-4-C-ethynyl-2-fluoro-β-D-arabinofuranosyl)-2-fluoro- Usage And Synthesis |
| Uses | CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases[1]. CL-197 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Hou J, et al. 4'-Ethynyl-2'-deoxy-2'-β-fluoro-2-fluoroadenosine: A Highly Potent and Orally Available Clinical Candidate for the Treatment of HIV-1 Infection. J Med Chem. 2023 Aug 24;66(16):11282-11293. DOI:10.1021/acs.jmedchem.3c00761 |
| | 9H-Purin-6-amine, 9-(2-deoxy-4-C-ethynyl-2-fluoro-β-D-arabinofuranosyl)-2-fluoro- Preparation Products And Raw materials |
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