| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | DL-3-Amino-3-(2-naphthyl)propionic acid Basic information |
| Product Name: | DL-3-Amino-3-(2-naphthyl)propionic acid | | Synonyms: | 3-amino-3-(2-naphthalenyl)propanoic acid;DL-3-Amino-3-(2-naphthyl)-propionic acid;DL-3-AMino-3-(2-naphthyl)propionic;3-AMino-3-(2-naphthyl)propionic acid;3-Amino-3-(naphthalen-2-yl)propanoic acid;DL-3-Amino-3-(2-phthyl)propionic acid;(RS)-3-Amino-3-(2-naphthyl)-propionic acid;2-Naphthalenepropanoic acid, β-amino- | | CAS: | 129042-57-5 | | MF: | C13H13NO2 | | MW: | 215.25 | | EINECS: | | | Product Categories: | | | Mol File: | 129042-57-5.mol |  |
| | DL-3-Amino-3-(2-naphthyl)propionic acid Chemical Properties |
| Melting point | 230-231 °C(Solvent: Water 50%; Ethanol) | | Boiling point | 412.337±33.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.252±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 3.431±0.12(predicted) | | Appearance | White to off-white Solid |
| | DL-3-Amino-3-(2-naphthyl)propionic acid Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-amino-3-(2-naphthalenyl)propionic acid from malonic acid and 2-naphthaldehyde was as follows: a mixture of 2.40 g of 2-naphthaldehyde (1-15 mmol), 2.44 g of malonic acid, and 3.54 g of ammonium acetate (molar ratio 1:1.1:2.3) was dissolved in 200 mL of 1-butanol, and the reaction was carried out at reflux for 1.5-2 hr, until the cessation of the release of carbon dioxide gas. Upon completion of the reaction, the precipitate formed was filtered and washed sequentially with boiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and 100 mL of water. The precipitate was dried at 80-100°C for 8-10 hours. The purity of the product was checked by thin layer chromatography (TLC) and the reaction yield was about 65-80%. | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268
[2] Chemistry - A European Journal, 2006, vol. 12, # 7, p. 1855 - 1874
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1952, p. 113,116
[4] Chem.Abstr., 1953, p. 2157 |
| | DL-3-Amino-3-(2-naphthyl)propionic acid Preparation Products And Raw materials |
|