Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-

Request For Quotation
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
Company Name: Wuhan Jingkangen Biomedical Technology Co., Ltd  
Tel: 13720134139 086-15871494362 13720134139
Email: orders@jknbiochem.com
Company Name: Shandong Dayou Pharmaceutical Research and Development Co., Ltd.  
Tel: hanfangpharma@126.com 15165037910
Email: hanfangpharma@126.com
Company Name: Olix ( Hubei) Pharmaceutical Technology Co., Ltd  
Tel: 17316404525 17316404525
Email: 209533805@qq.com
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd  
Tel: +86-0086-13720134139
Email: orders@jknbiochem.com
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Basic information
Product Name:Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-
Synonyms:Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-;KRAS G12D inhibitor 13
CAS:2648552-62-7
MF:C31H33F2N7O3
MW:589.64
EINECS:
Product Categories:
Mol File:2648552-62-7.mol
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Structure
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Chemical Properties
Boiling point 749.5±70.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka6.52±0.35(Predicted)
Safety Information
MSDS Information
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Usage And Synthesis
UsesKRAS G12D inhibitor 13 is a potent inhibitor of KRAS G12D. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 13 has the potential for the research of KRAS G12D-mediated cancer (extracted from patent WO2021108683A1, compound 142)[1].
References[1] Jennifer PITZEN, et al. Covalent ras inhibitors and uses thereof. Patent WO2021108683A1.
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]- Preparation Products And Raw materials
Tag:Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-[(2R,6R)-4-[(2S)-2-aziridinylcarbonyl]-2,6-dimethyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-(2648552-62-7) Related Product Information
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- Y-27632 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- RMC6291 RMC-7977 EHT1864