| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-89903882 18679456698 |
| Email: |
zilong@hizyme.com |
| Products Intro: |
Product Name:Ascofuranone
CAS:38462-04-3
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-0571-89903882 15990081639 |
| Email: |
sunshixuan@huidabiotech.com |
| Products Intro: |
Product Name:Ascofuranone
CAS:38462-04-3
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ascofuranone
CAS:38462-04-3
Package:100mg;25mg;50mg
|
|
| | ascofuranone Basic information |
| Product Name: | ascofuranone | | Synonyms: | ascofuranone;2-Methyl-3-chloro-4,6-dihydroxy-5-[(2E,6E)-3-methyl-7-[(2S)-4-oxo-5,5-dimethyltetrahydrofuran-2-yl]-2,6-octadienyl]benzaldehyde;3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(S)-tetrahydro-5,5-dimethyl-4-oxofuran-2-yl]-2,6-octadienyl]benzaldehyde;Ascofranone;Ascofuranon;(-)-Ascofuranone;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3-methyl-7-[(2S)-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl]-2,6-octadien-1-yl]- | | CAS: | 38462-04-3 | | MF: | C23H29ClO5 | | MW: | 420.93 | | EINECS: | | | Product Categories: | | | Mol File: | 38462-04-3.mol |  |
| | ascofuranone Chemical Properties |
| Melting point | 84 °C | | Boiling point | 581.2±50.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | pka | 6.32±0.50(Predicted) | | color | Needles from Me2CO/hexane |
| Toxicity | LD50 ipr-rat: 1350 mg/kg JANTAJ 26,681,73 |
| | ascofuranone Usage And Synthesis |
| Uses | (-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice. | | Definition | ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-). | | Safety Profile | Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-. |
| | ascofuranone Preparation Products And Raw materials |
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