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| | DX 9065a Basic information |
| Product Name: | DX 9065a | | Synonyms: | DX 9065a;(alphaS)-7-(Aminoiminomethyl)-alpha-[4-[[(3S)-1-(1-iminoethyl)-3-pyrrolidinyl]oxy]phenyl]-2-naphthalenepropanoic acid hydrochloride hydrate;2-Naphthalenepropanoic acid, 7-(aMinoiMinoMethyl)-α-[4-[[(3S)-1-(1-iMinoethyl)-3-pyrrolidinyl]oxy]phenyl]-, (Hydrochloride), hydrate (1:1:5), (αS)-;X-9065a;LJCBAPRMNYSDOP-LVCYMWGESA-N;DX-9065a Hydrochloride Pentahydrate;DX 9065;DX9065 | | CAS: | 155204-81-2 | | MF: | C26H31ClN4O4 | | MW: | 499.01 | | EINECS: | | | Product Categories: | | | Mol File: | 155204-81-2.mol |  |
| | DX 9065a Chemical Properties |
| | DX 9065a Usage And Synthesis |
| Uses | DX-9065a Hydrochloride Pentahydrate is used in the methods for cell transplantation therapy and use of factor Xa inhibitors for inhibiting the procoagulant activity associated with cell transplantation. | | in vivo | After i.v. injection to rabbits, DX-9065a displays prolonged anti-factor Xa activity and inhibition of thrombin generation[1].
After p.o. administration, DX-9065a causes a reduction in tissue factor-induced mortality of mice with ED50 value of 56 mg/kg[1].
When given i.v. to rats, DX-9065a exhibits a dose-dependent antithrombotic effect against factor Xa + stasis-induced venous thrombosis (ED50 = 1.2 mg/kg i.v.), but also in an arteriovenous shunt thrombosis model (ED50 = 8.1 mg/kg i.v.) without affecting bleeding time significantly. Similar effects were obtained after s.c. or p.o. administration[1].
In rabbits, after i.v., s.c. or p.o. administration, DX-9065a inhibits stasis-induced thrombosis after injection of tissue factor with ED50 values of 0.03 mg/kg, 0.3 mg/kg and 50.5 mg/kg, respectively. DX-9065a inhibits in a dose-dependent manner endotoxin-induced venous thrombosis in the rabbit (ED50 = 0.25 mg/kg i.v.) and reduces the decrease in platelet number and circulating fibrinogen levels in an experimental model of tissue factor-induced disseminated intravascular coagulation[1].
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| | DX 9065a Preparation Products And Raw materials |
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