nitroflurbiprofen manufacturers
- Nitroflurbiprofen
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- $46.00
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2026-07-17
- CAS:158836-71-6
- Purity: 99.88%
- Supply Ability: 10g
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| | nitroflurbiprofen Basic information |
| Product Name: | nitroflurbiprofen | | Synonyms: | nitroflurbiprofen;HCT 1206;Nitroxybutyl flurbiprofen;[1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester;Cyclooxygenase,Inhibitor,COX,Nitroflurbiprofen,HCT-1206,inhibit,HCT1206;Nitroflurbiprofen, 10 mM in DMSO | | CAS: | 158836-71-6 | | MF: | C19H20FNO5 | | MW: | 361.36 | | EINECS: | | | Product Categories: | | | Mol File: | 158836-71-6.mol |  |
| | nitroflurbiprofen Chemical Properties |
| Boiling point | 468.8±45.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Oil | | color | Colorless to light yellow |
| | nitroflurbiprofen Usage And Synthesis |
| Uses | Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. | | Definition | ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2. | | in vivo | In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1]. | | IC 50 | COX | | References | [1] Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19. DOI:10.1053/j.gastro.2006.12.041 |
| | nitroflurbiprofen Preparation Products And Raw materials |
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