GPX4-IN-13

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GPX4-IN-13 Suppliers list
Company Name: Jinan Jiuli Biotechnology Co. , Ltd.  
Tel: 15865264761
Email: 486064515@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
GPX4-IN-13 Basic information
Product Name:GPX4-IN-13
Synonyms:GPX4-IN-13;Benzonitrile, 4-[(2E)-3-[2-(2-formylphenoxy)phenyl]-1-oxo-2-propen-1-yl]-
CAS:2644044-43-7
MF:C23H15NO3
MW:353.37
EINECS:
Product Categories:
Mol File:2644044-43-7.mol
GPX4-IN-13 Structure
GPX4-IN-13 Chemical Properties
Boiling point 547.854±50.00 °C(Press: 760.00 Torr)(predicted)
density 1.274±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMSO: Sparingly soluble: 1-10 mg/ml
Safety Information
MSDS Information
GPX4-IN-13 Usage And Synthesis
UsesGPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM)[1].
References[1] Pamarthy, et al. "Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells." Drug Development Research 84.5 (2023): 861-887. DOI:10.1002/ddr.22059
GPX4-IN-13 Preparation Products And Raw materials
Tag:GPX4-IN-13(2644044-43-7) Related Product Information
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