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| | (S)-3-Piperidine-3-carboxylic acid Basic information |
| Product Name: | (S)-3-Piperidine-3-carboxylic acid | | Synonyms: | (3S)-3-Piperidinecarboxylic acid hydrochloride;(3S)-3-Piperidinecarboxylic acid hydrochloride salt;L(+)-NIPECOTIC ACID HCL;(S)-(+)-Nipecotic acid HCl;L(+)-nipecotic acid hydrochloride;(S)-3-Piperidine-3-CarboxylicAcid hydrochloride;(3S)-piperidine-3-carboxylic acid hydrochloride;(S)-3-Piperidine-3-carboxylic acid | | CAS: | 851956-01-9 | | MF: | C6H11NO2.ClH | | MW: | 165.62 | | EINECS: | | | Product Categories: | | | Mol File: | 851956-01-9.mol |  |
| | (S)-3-Piperidine-3-carboxylic acid Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid |
| | (S)-3-Piperidine-3-carboxylic acid Usage And Synthesis |
| Synthesis | The general steps for the synthesis of (S)-piperidine-3-carboxylic acid hydrochloride from N-Boc-(S)-3-carboxylic acid piperidine are as follows:
Step 1. Preparation of (3S)-piperidine-3-carboxylic acid hydrochloride
(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (4.0 g, 0.017 mol) was dissolved in dichloromethane (10 mL, 0.2 mol), and a 1,4-dioxane solution (30 mL) of 4.0 M hydrogen chloride was added. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the volatiles were removed by vacuum distillation to give (3S)-piperidine-3-carboxylic acid hydrochloride in quantitative yield. The crude product did not require further purification and could be used directly in subsequent steps.LCMS analysis showed m/z 166.2 (M + H)+. | | References | [1] Patent: US2006/4049, 2006, A1. Location in patent: Page/Page column 49
[2] Patent: WO2012/131379, 2012, A1. Location in patent: Page/Page column 25
[3] Patent: US2014/206703, 2014, A1. Location in patent: Paragraph 0106; 0107 |
| | (S)-3-Piperidine-3-carboxylic acid Preparation Products And Raw materials |
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