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| | 1-Methyl-1H-pyrrolo[2,3-b]pyridine Basic information |
| | 1-Methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties |
| Boiling point | 112-116 °C(Press: 21 Torr) | | density | 1.107 g/cm3(Temp: 22 °C) | | storage temp. | 2-8°C | | pka | 5.35±0.30(Predicted) | | Appearance | Light yellow to green yellow Liquid |
| | 1-Methyl-1H-pyrrolo[2,3-b]pyridine Usage And Synthesis |
| Uses | N-Methyl-d3-7-azaindole is a labeled reactant used in the preparation of blue fluorescent amino acids as in vivo building blocks for protein engineering. | | Synthesis | GENERAL METHODS: Preparation of known compound 1a: 7-azaindole (2 g, 16.95 mmol) and anhydrous DMF (10 mL) were added to a dry round-bottomed flask equipped with a magnetic stirring bar under nitrogen atmosphere. The reaction mixture was cooled to 0 °C, 60% sodium hydride (1.2 eq.) was added in batches and stirring was continued for 1 h at this temperature. Subsequently, iodomethane (1.1 eq.) was added slowly and dropwise, keeping the reaction temperature at 0 °C and continuing to stir for 1 hour. Upon completion of the reaction, the reaction was quenched with ice-cold water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 1-methyl-7-azaindole in quantitative yield. | | References | [1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 309 - 313
[2] Green Chemistry, 2017, vol. 19, # 23, p. 5559 - 5563
[3] Organic Letters, 2013, vol. 15, # 22, p. 5718 - 5721
[4] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 2, p. 255 - 267
[5] Journal of Natural Products, 2009, vol. 72, # 12, p. 2199 - 2202 |
| | 1-Methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials |
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