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| | Methyl 1-Boc-3-pyrrolidinecarboxylate Basic information | | Synthesis |
| | Methyl 1-Boc-3-pyrrolidinecarboxylate Chemical Properties |
| Boiling point | 105℃/0.2mm | | density | 1.120±0.06 g/cm3(Predicted) | | refractive index | 1.4560 to 1.4600 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | pka | -2.65±0.40(Predicted) | | color | Colorless to Light orange to Yellow | | InChI | InChI=1S/C11H19NO4/c1-11(2,3)16-10(14)12-6-5-8(7-12)9(13)15-4/h8H,5-7H2,1-4H3 | | InChIKey | LIWFYAVKYUQMRE-UHFFFAOYSA-N | | SMILES | N1(C(OC(C)(C)C)=O)CCC(C(OC)=O)C1 | | CAS DataBase Reference | 122684-33-7(CAS DataBase Reference) |
| | Methyl 1-Boc-3-pyrrolidinecarboxylate Usage And Synthesis |
| Synthesis | Methyl 1-benzylpyrrolidine-3-carboxylate (1.13 g) was dissolved in ethyl acetate (100 mL). Palladium on carbon (10%, 385 mg) was added to the solution, followed by di-tert-butyl dicarbonate (1.35 g, 6.18 mmol, 1.2 equivalents). The mixture was hydrogenated at room temperature for 8 hours. The suspension was filtered through diatomaceous earth, and the filtrate was concentrated under vacuum. The residue was purified by silica gel chromatography (75:25, hexane-ethyl acetate). 
Fig. Synthetic route of Methyl 1-Boc-3-pyrrolidinecarboxylate | | Chemical Properties | Colorless to Light orange to Yellow clear liquid | | Uses | Methyl 1-BOC-3-pyrrolidinecarboxylate is used as a synthetic intermediate. |
| | Methyl 1-Boc-3-pyrrolidinecarboxylate Preparation Products And Raw materials |
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