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| | Chloromethyl phenyl sulfone Basic information |
| | Chloromethyl phenyl sulfone Chemical Properties |
| Melting point | 51-53 °C (lit.) | | Boiling point | 130 °C / 1mmHg | | density | 1.336±0.06 g/cm3(Predicted) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Almost white | | BRN | 2046644 | | InChI | 1S/C7H7ClO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2 | | InChIKey | NXAIQSVCXQZNRY-UHFFFAOYSA-N | | SMILES | ClCS(=O)(=O)c1ccccc1 | | CAS DataBase Reference | 7205-98-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 21 | | HS Code | 29049095 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Chloromethyl phenyl sulfone Usage And Synthesis |
| Uses | Chloromethyl Phenyl Sulfone is used to synthesis of α,β-epoxy sulfones and aziridines; reacts with electrophilic arenes, heterocyclic arenes, and
alkenes; source of the α-phenylsulfonylmethyl radical. | | Preparation | Preparative Methods of Chloromethyl Phenyl Sulfone: several methods are available. The most convenient is the reaction of Sodium
Benzenesulfinate dihydrate with bromochloromethane in dimethyl sulfoxide. | | Synthesis | The general procedure for the synthesis of phenylmethyl sulfone and chloromethyl phenyl sulfone from methyl phenyl sulfide was as follows: 0.25 g (2 mmol) of methyl phenyl sulfide was used as a substrate and added to a 50 mL three-necked flask along with 10 mL of acetonitrile and 2 mL of water. The internal temperature of the flask was maintained at 23 °C. Subsequently, 0.09 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals were added in portions with continuous stirring. During the reaction, the internal temperature of the flask was increased to 28°C and then gradually decreased. GC analysis was performed 3 h after the start of the reaction and showed that 22% of the methyl phenyl sulfide was converted to methyl phenyl sulfoxide and 65% to methyl phenyl sulfone. By-products included 6% chloromethyl phenyl sulfoxide and 7% chloromethyl phenyl sulfone, and a total of 0.8% advanced chlorides. Addition of 0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was continued and stirring was continued for 1 hour. At this point, the methyl phenyl sulfide and methyl phenyl sulfoxide completely disappeared and the yield of methyl phenyl sulfone increased to 87%. Impurities included 11% chloromethyl phenyl sulfone, 0.5% dichloromethyl phenyl sulfone and 1.3% trichloromethyl phenyl sulfone. | | Solubility in organics | Chloromethyl Phenyl Sulfone is soluble in THF, CHCl3, CH2Cl2, and most organic solvents. | | References | [1] Patent: JP2017/52730, 2017, A. Location in patent: Paragraph 0046 |
| | Chloromethyl phenyl sulfone Preparation Products And Raw materials |
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