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| | 6,6'-Dichloro-2,2'-bipyridine Basic information |
| Product Name: | 6,6'-Dichloro-2,2'-bipyridine | | Synonyms: | 2,2'-Bi(6-chloropyridine);6,6'-Dichloro-2,2'-bipyridine;2-chloro-6-(6-chloropyridin-2-yl)pyridine;2,2'-Bipyridine, 6,6'-dichloro- | | CAS: | 53344-72-2 | | MF: | C10H6Cl2N2 | | MW: | 225.07 | | EINECS: | | | Product Categories: | | | Mol File: | 53344-72-2.mol |  |
| | 6,6'-Dichloro-2,2'-bipyridine Chemical Properties |
| Melting point | 220℃ (benzene ) | | Boiling point | 354.7±37.0 °C(Predicted) | | density | 1.363±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | Inert atmosphere,Room Temperature | | pka | -0.40±0.10(Predicted) | | Appearance | Off-white to pink Solid |
| | 6,6'-Dichloro-2,2'-bipyridine Usage And Synthesis |
| Synthesis | The synthesis of 6,6'-dichloro-2,2'-bipyridine (52a) was achieved by reacting a mixture of BuLi/Me2N(CH2)2OLi with 2-chloropyridine as starting material. This mixture served as a base for selective lithiation of the C-6 region (Scheme 23). The 6-lithium-2-chloropyridine generated during the reaction was further reacted with the starting material 2-chloropyridine to produce the target coupling product 52a in 47% yield. | | References | [1] Organic Letters, 2000, vol. 2, # 6, p. 803 - 805
[2] Patent: US2010/298562, 2010, A1. Location in patent: Page/Page column 34
[3] Phosphorus and Sulfur and the Related Elements, 1987, vol. 34, p. 123 - 132
[4] Patent: CN107935919, 2018, A. Location in patent: Paragraph 0049; 0051 |
| | 6,6'-Dichloro-2,2'-bipyridine Preparation Products And Raw materials |
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