- Glycycoumarin
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- $124.00
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2026-07-27
- CAS:94805-82-0
- Purity: 99.95%
- Supply Ability: 10g
- Glycycoumarin
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-
2026-02-02
- CAS:94805-82-0
- Min. Order: 5mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
- Glycycoumarin
-
-
2023-02-24
- CAS:94805-82-0
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one Basic information |
| Product Name: | 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one | | Synonyms: | 3-(2,4-Dihydroxyphenyl)-5-methoxy-6-(3-methyl-2-butenyl)-7-hydroxy-2H-1-benzopyran-2-one;3-(2,4-Dihydroxyphenyl)-6-(3-methyl-2-butenyl)-5-methoxy-7-hydroxy-2H-1-benzopyran-2-one;3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one;3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-2-one;Glycocoumarin - Glycyrrhiza uralensis (liquorice);2H-1-Benzopyran-2-one, 3-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-;Glycocoumarin -;inhibit,Glycycoumarin,Autophagy,Inhibitor | | CAS: | 94805-82-0 | | MF: | C21H20O6 | | MW: | 368.38 | | EINECS: | | | Product Categories: | | | Mol File: | 94805-82-0.mol |  |
| | 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one Chemical Properties |
| Melting point | 243.5-244.5℃ | | Boiling point | 646.9±55.0 °C(Predicted) | | density | 1.342±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 7.86±0.20(Predicted) | | form | solid | | color | white to beige | | biological source | plant | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChI | 1S/C21H20O6/c1-11(2)4-6-14-18(24)10-19-16(20(14)26-3)9-15(21(25)27-19)13-7-5-12(22)8-17(13)23/h4-5,7-10,22-24H,6H2,1-3H3 | | InChIKey | NZYSZZDSYIBYLC-UHFFFAOYSA-N | | SMILES | [o]1c2c(c(c(c(c2)O)CC=C(C)C)OC)cc([c]1=O)c3c(cc(cc3)O)O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one Usage And Synthesis |
| Uses | It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research. | | Definition | ChEBI: A member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 5, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis,
it exhibits antispasmodic activity. | | Biological Activity | Glycycoumarin is an isoflavone from vegetable roots including licorice th at exhibits potent hepatoprotective effects. Glycycoumarin protects hepatocytes through activation of autophagy and mitigation of ER stress/GSK-3 –JNK/CHOP-mitochondria cascade activation. Also, it appears to alleviate acetaminophen-induced liver injury through sustained autophagy. | | in vivo | Glycycoumarin (30 μM-0.3 nM; 5 min) has an inhibitory effect on smooth muscle contraction induced by various types of stimulants through the inhibition of PDEs, especially isozyme 3, followed by the accumulation of intracellular cAMP[1].
Glycycoumarin (10 mg/kg; i.p.; once daily for 4 d) enhances tumor growth inhibition in HepG2 xenograft model in mice and shows synergistical effect with ABT-737 (HY-50907)[2].
| Animal Model: | Male ICR mice (aged 6 weeks, weight 25-30 g)[1] | | Dosage: | 30 μM-0.3 nM, 5 min | | Administration: | | | Result: | Inhibited the contraction induced by various types of stimulants, such as CCh, KCI, BaCI(2), and A23187 (calcium ionophore III).
Enhanced the relaxation induced by forskolin on CCh-evoked contraction and also enhances the relaxation effect of rolipram.
Associated with dose-dependent accumulation of cAMP.
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| Animal Model: | HepG2 cancer cells xenograft model in male BALB/c athymic nude mice (6-7 weeks old)[2] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; once daily for 4 days; ABT-737 group was given 100 mg/kg i.p. | | Result: | Inhibited tumor growth and resulted a reduction of the final tumor weight by 17%. |
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| | 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one Preparation Products And Raw materials |
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