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- 4-METHYLESCULETIN
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2019-11-08
- CAS:529-84-0
- Min. Order: 1g
- Purity: 99.5%min
- Supply Ability: 20kg/week
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| | 4-Methylesculetin Basic information |
| Product Name: | 4-Methylesculetin | | Synonyms: | 6,7-DIHYDROXY-4-METHYL-CHROMEN-2-ONE;6,7-DIHYDROXY-4-METHYLCOUMARIN;METHYLESCULETIN, 4-;methylesculetin;6 7-DIHYDROXY-4-METHYLCOUMARIN FOR &;4-Methylesculetin, 98+%;(6,7-Dihydroxy-4-methylcoumarin)4-Methylesculetin;4-Methylesculetin,97% | | CAS: | 529-84-0 | | MF: | C10H8O4 | | MW: | 192.17 | | EINECS: | 208-470-0 | | Product Categories: | Coumarin;Fluorescent;Coumarins | | Mol File: | 529-84-0.mol |  |
| | 4-Methylesculetin Chemical Properties |
| Melting point | 274-276 °C(lit.) | | Boiling point | 248.14°C (rough estimate) | | density | 1.0825 (rough estimate) | | refractive index | 1.4440 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMF: soluble | | pka | 8.72(at 25℃) | | form | powder | | color | Light brown | | PH Range | Colorless (4.0) to blue 1 uorescent (6.2) | | λmax | 348nm, 292nm | | BRN | 162550 | | Major Application | Electroluminescent device, photoresists, photography, analytical reagent, cosmetics, hair dye, shampoo, antioxidant, hypotensive agent, antiimfiammatroy agent, antiviral agent, multidrug resistance (MDR) modulator, inhibitory effect onmelanin biosynthesis, protective agent against DNA damage, antimutagenic agent, detection of tumor cell-specific cytotoxicity, antiproliferative againt against cancer cells, analysis of human pancreatice cancer cell activity, chondroprotective agent | | LogP | 0.959 (est) | | CAS DataBase Reference | 529-84-0(CAS DataBase Reference) | | EPA Substance Registry System | 4-Methylesculetin (529-84-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 2 | | RTECS | GN6384500 | | F | 8 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29322985 |
| | 4-Methylesculetin Usage And Synthesis |
| Chemical Properties | GREY POWDER | | Uses | 6,7-Dihydroxy-4-methylcoumarin is suitable as a pH-indicator. | | Definition | ChEBI: 6,7-dihydroxy-4-methylcoumarin is a hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. It has a role as a hyaluronan synthesis inhibitor, an antioxidant and an anti-inflammatory agent. | | in vivo | 4-Methylesculetin (5 or 25 mg/kg, p.o., daily for 8 days) decreases MPO activity, reduces the colonic levels of IL-6 and counteracts GSH depletion, showing the intestinal antiinflammatory activity in Dextran sulfate sodium (DSS) rat model[1].
4-Methylesculetin (25 and 50 mg/kg, p.o., once a day from 11th day to 25th day) significantly prevents the swelling, bone and cartilage destruction at the joint in arthritic rats[2].
| Animal Model: | DSS rat model[1] | | Dosage: | 5 or 25 mg/kg | | Administration: | p.o., daily for 8 days | | Result: | Reduced MPO activity, IL-6 levels and counteracted GSH depletion induced by inflammatory process. |
| Animal Model: | Arthritic rats[2] | | Dosage: | 25 and 50 mg/kg | | Administration: | p.o., once a day from 11th day to 25th day | | Result: | Exhibited remarkable decline in paw volume and showed a prompt recovery of normal weight. |
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| | 4-Methylesculetin Preparation Products And Raw materials |
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