6'-N-Acetylneuramin-lactose sodium salt manufacturers
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| | 6'-N-Acetylneuramin-lactose sodium salt Basic information |
| Product Name: | 6'-N-Acetylneuramin-lactose sodium salt | | Synonyms: | 6'-Sialyllactose Sodium Salt (synthetic);6'-Sialyllactose Sodium Salt, from human milk;ALPHA-NEU5AC-[2->6]-BETA-D-GAL-[1->4]-D-GLC SODIUM SALT;6'-N-ACETYLNEURAMINYL LACTOSE, SODIUM SALT;6'-N-ACETYLNEURAMINYL LACTOSE, SODIUM SALT, HUMAN MILK;6'-SL, SODIUM SALT;NEU5AC-ALPHA2,6GAL-BETA1,4GLC, NA;N-[(2R,3R,4S,6R)-6-carboxy-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-6-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]oxan-3-yl]ethanimidate | | CAS: | 157574-76-0 | | MF: | C23H40NNaO19 | | MW: | 657.55 | | EINECS: | | | Product Categories: | | | Mol File: | 157574-76-0.mol |  |
| | 6'-N-Acetylneuramin-lactose sodium salt Chemical Properties |
| Melting point | 177-179°C | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly, Heated), Methanol (Slightly), Water (Sparingly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | InChIKey | WNDREJAZQDPQFB-LTDHETQONA-N | | SMILES | [Na+].[H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C([O-])=O)[C@H](O)[C@H](O)CO |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 6'-N-Acetylneuramin-lactose sodium salt Usage And Synthesis |
| Description | 6''-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose . Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus. These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum. | | Uses | 6''-Sialyllactose binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus. | | References | [1] PETER I DUNCAN. Sialic acid utilisation and synthesis in the neonatal rat revisited.[J]. PLoS ONE, 2009, 4 12: e8241. DOI: 10.1371/journal.pone.0008241
[2] NORBERT SPRENGER Peter I D. Sialic Acid Utilization[J]. Advances in Nutrition, 2012, 3 3: Pages 392S-397S. DOI: 10.3945/an.111.001479
[3] JASON A. ISKARPATYOTI . Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1[J]. Virology, 2012, 433 2: Pages 489-497. DOI: 10.1016/j.virol.2012.08.036
[4] URSULA NEU. Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands.[J]. PLoS Pathogens, 2013: e1003714. DOI: 10.1371/journal.ppat.1003714
[5] ANDREW ROSA BORGES . Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1[J]. Virology, 2010, 408 1: Pages 80-88. DOI: 10.1016/j.virol.2010.09.004
[6] WENXIN WU Gillian M A. Binding of influenza viruses to sialic acids: reassortant viruses with A/NWS/33 hemagglutinin bind to α2,8-linked sialic acid[J]. Virology, 2004, 325 2: Pages 340-350. DOI: 10.1016/j.virol.2004.05.013 |
| | 6'-N-Acetylneuramin-lactose sodium salt Preparation Products And Raw materials |
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