CONANTOKIN G

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CONANTOKIN G Basic information
Product Name:CONANTOKIN G
Synonyms:H-GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2;GLY-GLU-GAMMA-CARBOXYGLU-GAMMA-CARBOXYGLU-LEU-GLN-GAMMA-CARBOXYGLU-ASN-GLN-GAMMA-CARBOXYGLU-LEU-ILE-ARG-GAMMA-CARBOXYGLU-LYS-SER-ASN-NH2;GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2;GE(GLA)(GLA)LQ(GLA)NQ(GLA)LIR(GLA)KSN-NH2;CONANTOKIN G;CONANTOKIN G (MARINE SNAIL, CONUS GEOGRAPHUS);''SLEEPER PEPTIDE'';conotoxin GV
CAS:93438-65-4
MF:C88H138N26O44
MW:2264.19
EINECS:
Product Categories:ConantokinsCell Signaling and Neuroscience;Neuropeptides;Peptides for Cell Biology;Snail;Toxins and Venoms;Glutamate receptor
Mol File:93438-65-4.mol
CONANTOKIN G Structure
CONANTOKIN G Chemical Properties
RTECS GK5900000
storage temp. −20°C
solubility water: 1 mg/mL
form Solid
color white
Water Solubility Soluble in water at 1mg/ml
InChIKeyHTBKFGWATIYCSF-UHFFFAOYSA-N
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
CONANTOKIN G Usage And Synthesis
UsesNon-competitive inhibitor of NMDA glutamatergic receptors acting at the polyamine site. Conantokin G (CGX-1007), a member of the conantokin family, is a selective NR2B subunit inhibitor of NMDA glutamatergic receptors with activity as a neuroprotective agent against NMDA-induced excitotoxicity.
General DescriptionThe most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 μM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems.
Biochem/physiol ActionsPrimary TargetNMDA receptors
IC 50NMDA Receptor
CONANTOKIN G Preparation Products And Raw materials
Tag:CONANTOKIN G(93438-65-4) Related Product Information
conantokin ET (asn-oh17)-conantokin-G,CONANTOKIN G FREE ACID,CONANTOKIN G (TYR0)-CONANTOKIN G Conantokin T, Conus tulipa conantokin receptor conantokin R CONANTOKIN T,CONANTOKIN T (MARINE SNAIL, CONUS TULPA),CONANTOKIN T, MARINE SNAIL, CONUS TULLPA (GLU3,4,7,10,14)-CONANTOKIN G,[GLU3,4,7,10,14]-CONANTOKIN G GLY-GLU-GLU-GLU-LEU-GLN-GLU-ASN-GLN-GLU-LEU-ILE-ARG-GLU-LYS-SER-ASN-NH2 CONANTOKIN G