1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate

Request For Quotation
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Email: jkinfo@jkchemical.com
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: Ascent Scientific  
Tel: 4401179829988
Email: customerservice@ascentscientific.co.uk
Company Name: VDM Biochemicals   
Tel: 0330-2528181
Email: sales@vdmbio.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com

1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate manufacturers
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Basic information
Product Name:1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
Synonyms:JNJ 10191584 MALEATE;VUF 6002;JNJ 10191584 maleate salt;VUF 6002 maleate;VUF6002 maleate;JNJ 10191584 maleate (VUF 6002);JNJ 10191584 maleate (VUF 6002), Selective H4 antagonist;1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
CAS:869497-75-6
MF:C17H19ClN4O5
MW:394.80956
EINECS:
Product Categories:Other Enzyme Inhibitors and Activators.;Histamine;Other enzyme inhibitors and activators;Histamine receptor
Mol File:869497-75-6.mol
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Structure
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Chemical Properties
storage temp. Desiccate at RT
solubility DMSO: ≥10mg/mL
form powder
color off-white to light tan
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3
MSDS Information
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Usage And Synthesis
UsesA highly selective histamine H4 receptor silent antagonist
Biological ActivityHighly selective histamine H 4 receptor silent antagonist; binds with high affinity to the human H 4 receptor (K i = 26 nM) and is > 540-fold selective over the H 3 receptor (K i = 14.1 μ M). In vitro, inhibits mast cell and eosinophil chemotaxis with IC 50 values of 138 and 530 nM respectively. Orally active in vivo .
in vivo

JNJ10191584 maleate (10 μg/μL; intra locus coeruleus (LC) administration; once) abolishs VUF-induced anti-allodynic effect in spared nerve injury (SNI) mice[1]. JNJ10191584 maleate (10 μg/μL; intra LC administration; once) prevents the anti-allodynic effect of VUF 8430 in SNI mice[1]. JNJ10191584 maleate (6 μg/mouse; intrathecal administration; pretreat once) prevents VUF 8430-induced anti-allodynic effect in SNI mice[1].

IC 50Human H4 Receptor: 26 nM (Ki); human H3 receptor: 14.1 μM (Ki)
storageroom temperature (desiccate)
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate Preparation Products And Raw materials
Tag:1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate(869497-75-6) Related Product Information
1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate 1H-Benzimidazole-2-carboxaldehyde, 5-chloro- (6-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperazin-1-yl)-methanone IgG1 (mouse) Rabbit Monoclonal Antibody (Clone RM106) Methylprednisolone Ozanimod