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| | L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride Basic information |
| Product Name: | L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride | | Synonyms: | Ezatiostat hydrochloride;L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride;L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-D-phenylglycine diethyl ester monohydrochloride;Ezatiostat (TER199) HCl;Ezatiostat HCl;gamma-Glu-S-bzcys-phgly diethyl ester;Unii-D59N834676;Glycine,L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,diethyl ester, Monohydrochloride | | CAS: | 286942-97-0 | | MF: | C27H35N3O6S.ClH | | MW: | 566.11 | | EINECS: | | | Product Categories: | | | Mol File: | 286942-97-0.mol |  |
| | L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride Chemical Properties |
| solubility | >28.3mg/mL in DMSO | | form | Powder |
| | L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride Usage And Synthesis |
| Uses | Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment[1][2]. | | in vivo | Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/-animals[2]. | | References | [1] Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20 DOI:10.1186/1756-8722-5-20
[2] Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298(1):339-45. PMID:11408560 |
| | L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride Preparation Products And Raw materials |
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