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| | N-Boc-2-(4-aminophenyl)ethanol Basic information |
| Product Name: | N-Boc-2-(4-aminophenyl)ethanol | | Synonyms: | N-Boc-2-(4-aminophenyl)ethanol;N-Boc-2-(4-Aminophenyl);tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate;Carbamic acid, N-[4-(2-hydroxyethyl)phenyl]-, 1,1-dimethylethyl ester;2-[4-(Boc-amino)phenyl]ethanol;tert-Butyl (4-(2-hydroxyethyl)phenyl)carbamate | | CAS: | 104060-23-3 | | MF: | C13H19NO3 | | MW: | 237.29 | | EINECS: | | | Product Categories: | | | Mol File: | 104060-23-3.mol |  |
| | N-Boc-2-(4-aminophenyl)ethanol Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | N-Boc-2-(4-aminophenyl)ethanol Usage And Synthesis |
| Synthesis | Step 1. Preparation of tert-butyl 4-(2-hydroxyethyl)phenylcarbamate: Di-tert-butyl dicarbonate (1.75 g, 8.01 mmol) was added to a solution of ethyl acetate (10 ml) of 2-(4-aminophenyl)ethanol (1 g, 7.28 mmol). The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the reaction mixture was extracted by adding water and ethyl acetate to the reaction mixture. The organic layer was dried with anhydrous magnesium sulfate and the solvent was subsequently removed under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate=1:2) to afford 1.72 g (Yield: 99%, white solid) of N-Boc-2-(4-aminophenyl)ethanol.1H NMR (400 MHz, CDCl3): δ7.29 (d, J=8.4 Hz, 2H), 7.16 (d, J=8.4 Hz, 2H), 6.45 ( br s, 1H), 3.82(br s, 2H), 2.81(t, J=6.6Hz, 2H), 1.52(s, 9H). | | References | [1] Medicinal Chemistry Research, 2003, vol. 11, # 7, p. 380 - 398
[2] Patent: WO2009/61131, 2009, A2. Location in patent: Page/Page column 50
[3] Patent: WO2004/65402, 2004, A1. Location in patent: Page/Page column 148-149
[4] Patent: US6362360, 2002, B1. Location in patent: Example 1
[5] Patent: US2003/18207, 2003, A1 |
| | N-Boc-2-(4-aminophenyl)ethanol Preparation Products And Raw materials |
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