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| | 6-Chloro-3-Methylpyridine-2-carboxylic Acid Basic information |
| | 6-Chloro-3-Methylpyridine-2-carboxylic Acid Chemical Properties |
| Boiling point | 333.7±37.0 °C(Predicted) | | density | 1.390±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.93±0.32(Predicted) | | Appearance | White to off-white Solid |
| WGK Germany | 3 | | HS Code | 2933399990 |
| | 6-Chloro-3-Methylpyridine-2-carboxylic Acid Usage And Synthesis |
| Uses | 6-Chloro-3-methylpyridine-2-carboxylic Acid is disubstituted pyridinecarboxylic acid used in the preparation of biologically active compounds such as inhibitors of Janus kinases and PDK1. | | Synthesis | An aqueous 2N NaOH solution (5 mL) was slowly added dropwise to a stirred solution of methyl 6-chloro-3-methylpyridine-2-carboxylate (0.500 g, 2.702 mmol) in tetrahydrofuran (THF, 10 mL) at 0 °C. The reaction mixture was then warmed to 50 °C with continuous stirring for 2 hours. Upon completion of the reaction, the mixture was acidified to pH < 7 with aqueous citric acid and subsequently extracted with ethyl acetate (EtOAc, 2 × 10 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 6-chloro-3-methylpyridine-2-carboxylic acid as an off-white solid (0.45 g, 97% yield). The resulting product could be used in the subsequent reaction without further purification. Mass spectrometry (MS) analysis showed the molecular ion peak (m/z) of the target compound: 172.0 ([M+H]+). | | References | [1] Patent: WO2015/94912, 2015, A1. Location in patent: Page/Page column 12
[2] Patent: WO2014/4230, 2014, A1. Location in patent: Page/Page column 8; 45 |
| | 6-Chloro-3-Methylpyridine-2-carboxylic Acid Preparation Products And Raw materials |
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