CINANSERIN HYDROCHLORIDE
| 中文名称 | CINANSERIN HYDROCHLORIDE |
|---|---|
| 中文同义词 | N-(2-((3-(二甲氨基)丙基)硫代)苯基)-3-苯基丙烯酰胺盐酸盐;化合物CINANSERIN HYDROCHLORIDE;化合物CINANSERIN HYDROCHLORIDE,10 MM DMSO 溶液 |
| 英文名称 | Cinanserin hydrochloride |
| 英文同义词 | 2'-(3-DIMETHYLAMINOPROPYL-THIO)-CINNAMANILIDE HYDROCHLORIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE;N-[2-[[3-(DIMETHYLAMINO)PROPYL]THIO]PHENYL]-3-PHENYL-2-PROPENAMIDE HYDROCHLORIDE;2’-((3-(dimethylamino)propyl)thio)-cinnamanilidmonohydrochloride;maptc;n-(2-((3-(dimethylamino)propyl)thio)phenyl)-3-phenyl-2-propenamidmonohyd;sq10,643;DPTC 2'-(3-Dimethylaminopropylthio)cinnamanilide hydrochloride |
| CAS号 | 54-84-2 |
| 分子式 | C20H25ClN2OS |
| 分子量 | 376.95 |
| EINECS号 | |
| 相关类别 | amino |
| Mol文件 | 54-84-2.mol |
| 结构式 |  |
CINANSERIN HYDROCHLORIDE 性质
| 密度 | 1.22 g/cm3 |
|---|---|
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMSO：125 mg/mL（331.62 mM；需要超声） |
| 形态 | 粉末 |
| 颜色 | 浅黄至黄色 |
| 水溶解性 | Soluble to 50 mM in water |
|
5-HT 2 Receptor 41 nM (Ki) |
3C-like proteinase
|
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL
pro
, HCoV-229E 3CL
pro
, with the K
D
values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL
pro
and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL
pro
.
The IC
50
values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL
pro
are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC
50
values for HCoV-229E 3CL
pro
are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C
pro
at concentrations up to 200 μM.
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
| Animal Model: | Male Wistar rats (250 g) underwent thermal injury |
| Dosage: | 5 mg/kg |
| Administration: | Intravenous injection; for 2 hours |
| Result: | Significantly reduced systemic burn edema to shamburn levels.. |
安全信息
| 海关编码 | 2921490090 |
|---|