16-phenoxy tetranor Prostaglandin F2α methyl ester

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16-phenoxy tetranor Prostaglandin F2α methyl ester Basic information
Product Name:16-phenoxy tetranor Prostaglandin F2α methyl ester
Synonyms:16-phenoxy tetranor Prostaglandin F2.alpha. methyl ester;16-phenoxy tetranor Prostaglandin F2α methyl ester Exclusive;16-phenoxy tetranor Prostaglandin F2α methyl ester;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-, methyl ester, (5Z)-
CAS:51638-90-5
MF:C23H32O6
MW:404.5
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Mol File:51638-90-5.mol
16-phenoxy tetranor Prostaglandin F2α methyl ester Structure
16-phenoxy tetranor Prostaglandin F2α methyl ester Chemical Properties
storage temp. Store at -20°C
solubility DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): .5 mg/ml
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MSDS Information
16-phenoxy tetranor Prostaglandin F2α methyl ester Usage And Synthesis
DescriptionProstaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostaglandin F2α (16-phenoxy tetranor PGF2α) is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. 16-phenoxy tetranor PGF2α methyl ester is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
Uses16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid[1].
References[1] M Hayashi, Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain. J Med Chem. 1980 May;23(5):525-35. DOI:10.1021/jm00179a011
16-phenoxy tetranor Prostaglandin F2α methyl ester Preparation Products And Raw materials
Tag:16-phenoxy tetranor Prostaglandin F2α methyl ester(51638-90-5) Related Product Information
(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(S)-3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-hept-5-enoic acid methyl ester 16-phenoxy tetranor Prostaglandin F2α isopropyl ester (5Z)-N-(Cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-5-heptenamide 16-phenoxy tetranor Prostaglandin F2α methyl amide 16-Phenoxy tetranor prostaglandin f2alpha 15-Keto prostaglandin E2