16-phenoxy tetranor Prostaglandin F2α methyl amide

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16-phenoxy tetranor Prostaglandin F2α methyl amide Basic information
Product Name:16-phenoxy tetranor Prostaglandin F2α methyl amide
Synonyms:16-phenoxy tetranor Prostaglandin F2α methyl amide
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
16-phenoxy tetranor Prostaglandin F2α methyl amide Structure
16-phenoxy tetranor Prostaglandin F2α methyl amide Chemical Properties
solubility DMF: 100 mg/ml
DMSO: 100 mg/ml
Ethanol: 100 mg/mlPBS (pH 7.2): .5 mg/ml
Safety Information
MSDS Information
16-phenoxy tetranor Prostaglandin F2α methyl amide Usage And Synthesis
DescriptionProstaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor PGF2α is a metabolically stable form of PGF2α containing a 16-phenoxy group at the ω-terminus. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.1 16-phenoxy tetranor PGF2α methyl amide is a lipophilic analog of 16-phenoxy tetranor PGF2α. Methyl amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.WARNING This product is not for human or veterinary use.
References[1] ANIL K. BALAPURE . Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor[J]. Biochemical pharmacology, 1989, 38 14: Pages 2375-2381. DOI: 10.1016/0006-2952(89)90478-4
16-phenoxy tetranor Prostaglandin F2α methyl amide Preparation Products And Raw materials
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16-phenoxy tetranor Prostaglandin F2α isopropyl ester (5Z)-N-(Cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-5-heptenamide 16-phenoxy tetranor Prostaglandin F2α methyl ester 16-(3-fluorophenoxy) tetranor Prostaglandin F2α methyl amide 16-Phenoxy tetranor prostaglandin f2alpha