| Company Name: |
ChemeGen |
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18818260767 |
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2625930290@qq.com |
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| | Methylcarbamyl PAF C-8 Basic information |
| | Methylcarbamyl PAF C-8 Chemical Properties |
| solubility | DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 25 mg/ml |
| | Methylcarbamyl PAF C-8 Usage And Synthesis |
| Description | Methylcarbamyl PAF C-8 is the C-8 analog of Methylcarbamyl PAF C-16. Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc, c-fos, and the activation of mitogen-activated protein kinase.2 Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2WARNING This product is not for human or veterinary use. | | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] K KUME T S. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor.[J]. The Journal of Biological Chemistry, 1997, 272 36: 22898-22904. DOI: 10.1074/jbc.272.36.22898 |
| | Methylcarbamyl PAF C-8 Preparation Products And Raw materials |
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