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| | 1-O-HEXADECYL-(7,7,8,8-D4)-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE Basic information |
| | 1-O-HEXADECYL-(7,7,8,8-D4)-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS pH 7.2: 25 mg/ml | | form | Liquid | | color | Colorless to light yellow | | Water Solubility | Water: 30 mg/ml |
| | 1-O-HEXADECYL-(7,7,8,8-D4)-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE Usage And Synthesis |
| Description | PAF C-16-d4 contains four deuterium atoms at the 7, 7'', 8, and 8'' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and ''de novo'' pathways. It is a potent mediator of neutrophil migration, the production of reactive oxygen species, and IL-6 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-18. Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy. | | Uses | 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine-d4 is the deuterium labeled 1-Palmityl-2-O-acetyl-3-glyceryl phosphorylcholine[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110 |
| | 1-O-HEXADECYL-(7,7,8,8-D4)-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE Preparation Products And Raw materials |
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