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1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

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1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea Basic information
Product Name:1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
Synonyms:RKI-1313;1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea;RKI-1313 (Negative control of RKI-1447);RKI1313;RKI 1313;PKI 1313;PKI1313;PKI1313;PKI 1313;Urea, N-[(3-methoxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]-
CAS:1342276-76-9
MF:C17H16N4O2S
MW:340.4
EINECS:
Product Categories:Inhibitors
Mol File:1342276-76-9.mol
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea Structure
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea Chemical Properties
density 1.323±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30mg/mL; DMSO: 30mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
form A crystalline solid
pka6.38±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea Usage And Synthesis
DescriptionRKI-1313 is an inhibitor of Rho-associated kinase 1 (ROCK1) and 2 (IC50s = 34 and 8 μM, respectively). It has been used as a negative control for the ROCK inhibitor RKI-1447 .
UsesRKI-1313 is a ROCK inhibitor with IC50s of 34, 8 μM for ROCK 1 and ROCK 2, respectively. RKI-1313 shows little effect on the phosphorylation levels of ROCK substrates, migration, invasion or anchorage-independent growth[1].
IC 50ROCK1: 34 μM (IC50); ROCK2: 8 μM (IC50)
References[1] Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. DOI:10.1158/0008-5472.CAN-12-0954
1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea Preparation Products And Raw materials
Tag:1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea(1342276-76-9) Related Product Information
RK-33 1-cyclopentyl-3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]urea 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea (Z)-3-methoxy-N-(4-phenylthiazol-2(3H)-ylidene)benzamide RKI1447 2-Thiazolamine, 4-(4-methoxyphenyl)-N-(phenylmethyl)-