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| | DesfluoroMethyl Fluticasone Propionate Disulfide Basic information |
| Product Name: | DesfluoroMethyl Fluticasone Propionate Disulfide | | Synonyms: | Androsta-1,4-dien-3-one, 17,17'- (dithiodicarbonyl)bis[6,9- difluoro-11-hydroxy-16-Methyl-17-(1-oxopropoxy)-, (6α,11β, 16α,17α)-(6'α,11'β,16'α,17'α)-;Fluticasone Propionate Disulfide Dimer Impurity;Fluticasone Propionate EP Impurity H;Fluticasone Disulphane Impurity;Fluticasone Impurity 9;DesfluoroMethyl Fluticasone Propionate Disulfide;Fluticasone Impurity 8(Fluticasone EP Impurity H);Propionate Impurity H | | CAS: | 201812-64-8 | | MF: | C48H58F4O10S2 | | MW: | 935.09 | | EINECS: | | | Product Categories: | Pharmaceuticals, Intermediates & Fine Chemicals, Steroids | | Mol File: | 201812-64-8.mol |  |
| | DesfluoroMethyl Fluticasone Propionate Disulfide Chemical Properties |
| Melting point | >200°C | | Boiling point | 905.0±75.0 °C(Predicted) | | density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly) | | pka | 12.20±0.70(Predicted) | | form | Solid | | color | Off-White to Light Yellow |
| | DesfluoroMethyl Fluticasone Propionate Disulfide Usage And Synthesis |
| Uses | Desfluoromethyl Fluticasone Propionate Disulfide is the disulfide conjugated dimer of Fluticasone Propionate (F599500), a derivative of flumethasone and an anti-inflammatory agent. | | Synthesis | This is an impurity formed during the synthesis of Fluticasone Propionate. Its formation involves key steps: oxidative cleavage of the C-17 hydroxymethyl group in flumetasone, activation of the resulting acid and reaction with HS to give a thiocarboxylic acid, esterification of the C-17 hydroxyl, and S-alkylation of the thiocarboxylic acid with bromochloromethane. |
| | DesfluoroMethyl Fluticasone Propionate Disulfide Preparation Products And Raw materials |
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