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| | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Basic information |
| Product Name: | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine | | Synonyms: | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine;2-chloro-N-ethyl-5-(trifluoromethyl)-4-Pyrimidinamine;4-Pyrimidinamine, 2-chloro-N-ethyl-5-(trifluoromethyl)-;(2-Chloro-5-trifluoromethyl-pyrimidin-4-yl)-ethyl-amine;2-chloro-4-(ethylamino)-5-(trifluoromethyl)pyrimidine;2-chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-4-amine - [C82608];2-chloro-N-ethyl-5-(trifluoromethyl)pyrimidin-4-amine | | CAS: | 1374829-47-6 | | MF: | C7H7ClF3N3 | | MW: | 225.6 | | EINECS: | | | Product Categories: | | | Mol File: | 1374829-47-6.mol |  |
| | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Chemical Properties |
| Boiling point | 319.1±42.0 °C(Predicted) | | density | 1.434±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 0.63±0.10(Predicted) | | Appearance | White to light yellow Solid |
| | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Usage And Synthesis |
| Synthesis | A solution of 2,4-dichloro-5-(trifluoromethyl)pyrimidine (70 g, 322.61 mmol) in THF (1.4 L) was treated with a solution of ethanolamine (32 g, 709.74 mmol, 46.37 mL) in THF (100 mL) at 0°C, dropwise under N2, over 1 hour. Once the addition was complete, the mixture was stirred at 25°C for 1 hour. The mixture was then filtered and concentrated under reduced pressure to obtain a residue. The residue was subsequently triturated with DCM (200 mL) and filtered. The filtrate was recrystallized with a mixture of n-heptane (600 mL) and MTBE (400 mL). The resulting phase was syrup-like in consistency, and the liquid phase was discarded. The syrup residue was further purified by silica gel column chromatography (PE: EtOAc=20:1) to yield 4-chloro-N-ethyl-5-(trifluoromethyl) pyrimidine-2-amine as a white solid.
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| | 4-chloro-N-ethyl-5-(trifluoroMethyl)pyriMidin-2-aMine Preparation Products And Raw materials |
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