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| | L-Asparagine:H2O (2,3,3-d3, 94%) Basic information |
| | L-Asparagine:H2O (2,3,3-d3, 94%) Chemical Properties |
| storage temp. | -20°C | | solubility | 1N HCl: soluble | | form | A solid | | color | White to off-white | | CAS Number Unlabeled | 5794-13-8 |
| | L-Asparagine:H2O (2,3,3-d3, 94%) Usage And Synthesis |
| Uses | L-Asparagine-d3 (hydrate) is the deuterium labeled L-Asparagine. L-Asparagine ((-)-Asparagine) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. | | Biological Activity | L-Asparagine-d3 is intended for use as an internal standard for the quantification of L-asparagine by GC- or LC-MS. L-Asparagine is a non-essential amino acid.1 It is formed from L-aspartic acid and L-glutamine by asparagine synthetase (ASNS), and it is deamidated by L-asparaginase to produce L-aspartic acid and ammonia.2,3 L-Asparagine (0.3 mM) reverses ASNS siRNA knockdown-induced decreases in proliferation in a panel of six human cancer cell lines, indicating that both exogenous and endogenous L-asparagine promote proliferation of these cells.4 Formulations containing L-asparagine have been used as dietary supplements. | | References | 1.Chiu, M.I., Taurino, G., Bianchi, M.G., et al.Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemiaFront. Oncol.91480(2020)
2.Zhu, W., Radadiya, A., Bisson, C., et al.High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivityCommun. Biol.2345(2019)
3.Covini, D., Tardito, S., Bussolati, O., et al.Expanding targets for a metabolic therapy of cancer: L-AsparaginaseRecent Pat. Anticancer Drug Discov.7(1)4-13(2012)
4.Pathria, G., Lee, J.S., Hasnis, E., et al.Translational reprogramming marks adaptation to asparagine restriction in cancerNat. Cell Biol.21(12)1590-1603(2019) |
| | L-Asparagine:H2O (2,3,3-d3, 94%) Preparation Products And Raw materials |
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