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| | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane Basic information |
| Product Name: | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane | | Synonyms: | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane;2,4-Dimethyl-1-[(2-nitrophenyl)thio]benzene;(2,4-Dimethyiphenyl)(2-Nitrophenyl)Sulfane;VOR-IM A;Benzene, 2,4-dimethyl-1-[(2-nitrophenyl)thio]-;2,4-Dimethyl-1-[(2-nitrophenyl)sulfanyl]benzene;Vortioxetine Impurity 32;1-Nitro-2-((2,4-dimethylphenyl)thio)benzene | | CAS: | 1610527-49-5 | | MF: | C14H13NO2S | | MW: | 259.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1610527-49-5.mol |  |
| | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane Chemical Properties |
| Boiling point | 353.9±30.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Light yellow to yellow Solid |
| | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane Usage And Synthesis |
| Uses | (2,4-Dimethylphenyl)(2-nitrophenyl)sulfane is a reacatnat in studying generic industry approach to efficient purification of potential mutagenic impurities in the synthesis of drug substances. | | Synthesis | Dissolve 50.00 g (0.36 mol) of 2,4- dimethylbenzenethiol (5) in 300 mL of DMF, add 30.44 g () of potassium hydroxide and stir at room temperature.
0.5425mol) of potassium hydroxide, stir at room temperature, add a total of 56.99 g (0.3617 mol) of o-chloronitrobenzene (6) in 3 batches, and react at 50 .
The reaction was carried out at 50 for 5 h. The reaction was monitored by thin-layer chromatography (TLC), and the unfolding reagent was [ ethyl acetate: petroleum ether (AR bp: 60 ~90 )=1:5] .
The reaction was monitored by TLC. After the reaction was completed and cooled to room temperature, 900 mL of distilled water was added with thorough stirring, a large amount of solid was precipitated, and the filter cake was filtered and recrystallized with ethanol to obtain 89.10 g of compound 4. Yield 95%, mp: 98.0%.
95%, mp: 98 ~100 , MS: C 14 H 13 NO 2 S [M+Na] + 282.0563 . |
| | (2,4-diMethylphenyl)(2-nitrophenyl)sulfane Preparation Products And Raw materials |
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