| Company Name: |
ACROBiosystems |
| Tel: |
13121935750 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| Product Name: | XCT | | Synonyms: | Anti-SLC7A11 antibody produced in rabbit;CCBR1;Cystine/glutamate transporter;XCT;amino acid transport system xc-;calcium channel blocker resistance protein 1;solute carrier family 7 member 11;Anti-SLC7A11 Antibody (2U673) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![XCT Structure]() |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 1 | | Storage Class | 12 - Non Combustible Liquids |
| Uses | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. | | Biological Activity | Solute carrier family 7, membrane 11 (SLC7A11) or xCT participates in glutathione homeostasis, th at helps to guard the cells against oxidative stress. It is involved in the pathogenesis of malignant tumors. SLC7A11 is associated with triple negative breast cancer and glioblastoma (GBM). |
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