- (R)-Styrene oxide
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2025-04-04
- CAS:20780-53-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| | (R)-Styrene oxide Chemical Properties |
| Melting point | -37 °C | | alpha | -21 º (c=5, chloroform 23 ºC) | | Boiling point | 89-90 °C23 mm Hg(lit.) | | density | 1.051 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.535 | | Fp | 175 °F | | storage temp. | 2-8°C | | solubility | Chloroform | | form | Liquid | | color | Clear yellow | | explosive limit | ~22% | | Optical Rotation | [α]20/D +33°, neat | | Water Solubility | insoluble | | BRN | 1984 | | InChI | 1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2/t8-/m0/s1 | | InChIKey | AWMVMTVKBNGEAK-QMMMGPOBSA-N | | SMILES | C1O[C@@H]1c2ccccc2 | | CAS DataBase Reference | 20780-53-4(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, (epoxyethyl)-, (R)-(20780-53-4) |
| Hazard Codes | T | | Risk Statements | 45-21-36 | | Safety Statements | 53-45 | | RIDADR | 2810 | | WGK Germany | 3 | | RTECS | CZ9625010 | | F | 10 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29109000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Dermal
Carc. 1B
Eye Irrit. 2 |
| | (R)-Styrene oxide Usage And Synthesis |
| Preparation | (R)-2-hydroxy-2-phenylethylmethanesulfonic acid (1.4 g) and 28% sodium methoxide (1.25 g) were added to methanol (10 ml) and stirred at room temperature for 1 hour. The reaction mixture was neutralized, concentrated, and then ethyl acetate and water were added to the residue. The organic layer was collected by separation, washed with saturated sodium chloride aqueous solution, and then dehydrated and dried with magnesium sulfate. The desiccant was filtered off, and the solvent was distilled off under reduced pressure. The resulting oily substance was then distilled under reduced pressure to give a colorless oily compound (R)-Styrene oxide (0.7 g, 90.0%). | | Chemical Properties | Colorless to light yellow liqui | | Uses | Main metabolite of Styrene (S687790), catalyzed by epoxide hydrolase. | | Uses | It is used to produce a homologated epoxide as part of a synthetic approach to (+)-allosedamine. It is the main metabolite of styrene, catalyzed by epoxide hydrolase. | | Definition | ChEBI: The (R)-enantiomer of styrene oxide. |
| | (R)-Styrene oxide Preparation Products And Raw materials |
| Raw materials | 1,2-Ethanediol, 1-phenyl-, 2-methanesulfonate, (1R)--->1,3-Dioxolan-2-one, 4-phenyl-, (4R)--->Carbamic acid, N-[(2S)-2-hydroxy-2-phenylethyl]-, phenylmethyl ester-->alpha-(bromomethyl)benzyl alcohol-->(S)-N-Boc-2-hydroxy-2-phenylethylamine-->(S)-2-CHLORO-1-PHENYL-ETHANOL-->(R)-2-CHLORO-1-PHENYLETHANOL-->(+/-)-2-CHLORO-1-PHENYLETHANOL-->(1S)-2-bromo-1-phenyl-ethanol-->(S)-Styrene oxide-->(S)-(+)-1-Phenyl-1,2-ethanediol-->(R)-(-)-1-Phenyl-1,2-ethanediol-->Benzyl carbamate |
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