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9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone

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9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone manufacturers
9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone Basic information
Product Name:9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone
Synonyms:pgf2-alpha1,15-lactone;prosta-5,13-dien-1-oicacid,9,11,15-trihydroxy-,lambda-lactone,(5z,9-alpha,1;u47473;Prostaglandin F2α 1,15-lactone;PROSTAGLANDIN F2ALPHA 1,15-LACTONE;13e,15s)-1-alph;(1R,3Z,10S,11E,13R,14R,16S)-14,16-dihydroxy-10-pentyl-9-oxabicyclo[11.3.0]hexadeca-3,11-dien-8-one;9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone
CAS:55314-49-3
MF:C20H32O4
MW:336.47
EINECS:
Product Categories:
Mol File:55314-49-3.mol
9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone Structure
9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone Chemical Properties
storage temp. Store at -20°C
solubility DMF: >20.4 mg/ml; DMSO: >10 mg/ml; Ethanol: >105 mg/ml; Ethanol:PBS (30:70): 8 mg/ml; PBS (pH 7.2): <50 ug/ml
form A crystalline solid
Safety Information
MSDS Information
9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone Usage And Synthesis
DescriptionPGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective.
UsesPGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey[1].
in vivo

PGF2α 1,15-lactone (5 mg for i.v.; 3 mg for intramuscularly) terminates early pregnancy in the monkey[1].

Animal Model:Rhesus monkey (trimester pregnant)[1]
Dosage:5 mg for i.v.; 3 mg for intramuscularly
Administration:IV on days 30 and 31, 31 and 32, or 33 and 34; Intramuscularly on days 29 and 30, 30 and 31, or 33 and 34
Result:Aborted between 36 and 48 hr after treatment, Within 10 minutes after treatment there was a significant increase in uterine tone and frequency of contractions.
References[1] Spilman CH, et al. Effects of PGF2alpha and PGF2alpha, 1-15 lactone on the corpus luteum and on early pregnancy in the rhesus monkey. Prostaglandins. 1977 Sep;14(3):477-88. DOI:10.1016/0090-6980(77)90262-3
9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone Preparation Products And Raw materials
Raw materialsProsta-5,13-dien-1-oic acid, 9,11-[(butylborylene)bis(oxy)]-15-hydroxy-, λ-lactone, (5Z,9α,11α,13E,15S)- (9CI)
Tag:9alpha, 11alpha, 15S-trihydroxy-prosta-5z, 13e-dien-1-oic acid, 1,15-lactone(55314-49-3) Related Product Information
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