|
|
| | endo-BCN-PEG2-PFP ester Basic information |
| Product Name: | endo-BCN-PEG2-PFP ester | | Synonyms: | endo-BCN-PEG2-PFP ester;4,7,12-Trioxa-10-azatridecanoic acid, 13-bicyclo[6.1.0]non-4-yn-9-yl-11-oxo-, 2,3,4,5,6-pentafluorophenyl ester | | CAS: | 1421932-53-7 | | MF: | C24H26F5NO6 | | MW: | 519.46 | | EINECS: | | | Product Categories: | | | Mol File: | 1421932-53-7.mol |  |
| | endo-BCN-PEG2-PFP ester Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF |
| | endo-BCN-PEG2-PFP ester Usage And Synthesis |
| Description | endo-BCN-PEG2-PFP ester is a click chemistry active ester. The PFP esters have similar applications as the NHS esters, but are more stable in aqueous solution. They can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group can react with azide-tagged biomolecules. | | Uses | endo-BCN-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG2-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | endo-BCN-PEG2-PFP ester Preparation Products And Raw materials |
|