- Podocarpic acid
-
- $56.00
-
2026-05-11
- CAS:5947-49-9
- Purity: 99.88%
- Supply Ability: 10g
- Podocarpic acid
-
- $56.00
-
2026-04-20
- CAS:5947-49-9
- Purity: 99.88%
- Supply Ability: 10g
|
| | Podocarpic acid Basic information |
| Product Name: | Podocarpic acid | | Synonyms: | (1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid;1,4-alpha-Dimethyl-6-hydroxy-1,2,3,4-alpha-9,10,10-alpha-octahydro-1-phenanthrenecarboxylicacid;1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S,4aS,10aR)-;1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy -1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI);(1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid;(1S)-1,4aβ-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid;[1S,(+)]-1,2,3,4,4a,9,10,10aα-Octahydro-6-hydroxy-1,4aβ-dimethyl-1β-phenanthrenecarboxylic acid;(1R)-1,4aα-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aβ-octahydrophenanthrene-1α-carboxylic acid | | CAS: | 5947-49-9 | | MF: | C17H22O3 | | MW: | 274.35 | | EINECS: | 227-706-3 | | Product Categories: | Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules | | Mol File: | 5947-49-9.mol |  |
| | Podocarpic acid Chemical Properties |
| Melting point | 193-196 °C (lit.) | | alpha | 20546 +165° (c = 4 in abs ethanol) | | Boiling point | 449.6±45.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 100 mg/mL (364.50 mM) | | pka | 4.66±0.40(Predicted) | | form | Solid | | color | White to off-white | | Optical Rotation | [α]20/D +133°, c = 4 in ethanol | | Merck | 13,7625 | | InChI | 1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1 | | InChIKey | VJILEYKNALCDDV-OIISXLGYSA-N | | SMILES | [H][C@@]12CCc3ccc(O)cc3[C@@]1(C)CCC[C@]2(C)C(O)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | Podocarpic acid Usage And Synthesis |
| Uses | Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator. | | Definition | ChEBI: An abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position. | | in vivo | Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca2+ flux, which is significantly reduces when the Ca2+-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels[1]. | | References | [1] Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7. DOI:10.1055/s-0029-1240738
[2] Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8. DOI:10.1016/j.bmcl.2005.03.100 |
| | Podocarpic acid Preparation Products And Raw materials |
|