N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide

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N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide manufacturers

  • AZD4721
  • AZD4721 pictures
  • 2026-04-22
  • CAS:1418112-77-2
  • Purity:
  • Supply Ability: 10g
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide Basic information
Product Name:N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide
Synonyms:N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide;EOS-61288;AZD-4721;1-Azetidinesulfonamide, N-[6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-2-[[(4-fluorophenyl)methyl]thio]-4-pyrimidinyl]-3-methyl-;Vimnerixin;Vimnerixin (AZD4721
CAS:1418112-77-2
MF:C19H25FN4O5S2
MW:472.55
EINECS:
Product Categories:
Mol File:1418112-77-2.mol
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide Structure
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide Chemical Properties
storage temp. Store at -20°C
form Solid
color White to off-white
Safety Information
MSDS Information
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide Usage And Synthesis
UsesVimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease[1].
in vivo

Assessment of Pharmacokinetics (PK) profile of Vimnerixin in rat and dog[1]
.

In Vivo PKRatDog
Predicted hepatic metabolic CL (ml/min per kilogram)1.70.80
Observed CL (ml/min per kilogram)2.40.50
CLrenal (mL/min per kilogram)<0.01<0.01
CLbiliary (mL/min per kilogram)<0.010.04
In vivo/in vitro unbound CLintc1.40.6
VSS (l/kg)0.190.15
T1/2 (h) (PO)1.33.7
(2.7)(8.4)
F (%)4582
References[1] Gardiner P, et al. Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metab Dispos. 2019;47(8):865-873. DOI:10.1124/dmd.119.087163
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide Preparation Products And Raw materials
Tag:N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide(1418112-77-2) Related Product Information
N-(6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)-2-((4-fluorobenzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide AZD-5069 BCA-1/CXCL13 Protein, MOUSE (HEK293, HIS) I-TAC/CXCL11 Protein, Mouse BL-8040 Ulocuplumab