- AZD-5069
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- $31.00
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2026-07-27
- CAS:878385-84-3
- Purity: 99.92%
- Supply Ability: 10g
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| | AZD-5069 Basic information |
| Product Name: | AZD-5069 | | Synonyms: | AZD-5069;ACT-281959;CPDD1543;AZD 5069; AZD5069;CS-2808;AZD-5069; AZD 5069; AZD5069;878385-84-3;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide;1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]- | | CAS: | 878385-84-3 | | MF: | C18H22F2N4O5S2 | | MW: | 476.52 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 878385-84-3.mol |  |
| | AZD-5069 Chemical Properties |
| Melting point | 149-152°C | | Boiling point | 680.5±65.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 4.56±0.20(Predicted) | | form | Solid | | color | White to Off-White |
| | AZD-5069 Usage And Synthesis |
| Description | AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment. | | Uses | AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions. | | Biological Activity | AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation. | | IC 50 | 125I-IL-8-CXCR2 |
| | AZD-5069 Preparation Products And Raw materials |
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