- (1H-PYRAZOL-3-YL)METHANOL
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- $15.00 / 1KG
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2021-07-02
- CAS:23585-49-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 1H-pyrazol-5-ylmethanol
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- $5.50 / 1KG
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2020-01-10
- CAS:23585-49-1
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1kg,10kg,100kg
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| | (1H-PYRAZOL-3-YL)METHANOL Basic information |
| Product Name: | (1H-PYRAZOL-3-YL)METHANOL | | Synonyms: | 3-(HYDROXYMETHYL)PYRAZOLE;1H-PYRAZOLE-3-METHANOL;(1H-PYRAZOL-3-YL)METHANOL;1H-pyarzole-3-methanol;3-HyroxyMethyl-1H-pyrazole;3-HyroxyMethyl-1H-pyrazol...;1H-Pyrazole-3-methanol (9CI, ACI);1H-Pyrazole-3-methanol 95% | | CAS: | 23585-49-1 | | MF: | C4H6N2O | | MW: | 98.1 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 23585-49-1.mol |  |
| | (1H-PYRAZOL-3-YL)METHANOL Chemical Properties |
| Melting point | 184-185 °C | | Boiling point | 137-140 °C(Press: 0.5 Torr) | | density | 1.225 g/cm3(Temp: 25 °C) | | storage temp. | 2-8°C | | pka | 13.59±0.10(Predicted) | | form | solid | | color | Off White |
| | (1H-PYRAZOL-3-YL)METHANOL Usage And Synthesis |
| Chemical Properties | Colorless Liquid | | Synthesis | General procedure for the synthesis of 3-(hydroxymethyl)pyrazole from 1H-pyrazole-3-carboxylic acid: a tetrahydrofuran solution (20 mL) of aluminum (III) hydride was cooled to 0 °C under nitrogen protection and stirred. To this solution was added 1H-pyrazole-3-carboxylic acid (4 g, 35.7 mmol). The reaction mixture was stirred at room temperature for 1 hour and then heated to reflux overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and water (2.7 mL), 10% NaOH solution (5.4 mL) and water (8.1 mL) were added sequentially to quench the reaction. After quenching, the mixture was continued to be stirred at 0 °C for 30 min and then filtered through a Celite pad. The filtrate was concentrated under reduced pressure to remove the solvent and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1/2, v/v) to afford the target product (1H-pyrazol-3-yl)methanol (1.9 g, 19.37 mmol, 54% yield) as a buttery solid. m/z = 81.1 [M + H - H2O]+ was shown by LCMS detection. | | References | [1] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 968
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175 |
| | (1H-PYRAZOL-3-YL)METHANOL Preparation Products And Raw materials |
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