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| | 5-Fluoro-7-methoxyquinazolin-4(3H)-one Basic information |
| | 5-Fluoro-7-methoxyquinazolin-4(3H)-one Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | Off-white to pale purple Solid |
| | 5-Fluoro-7-methoxyquinazolin-4(3H)-one Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-fluoro-7-methoxy-4(3H)-ones from 2-amino-6-fluoro-4-methoxybenzonitrile and formic acid: To a mixed solution containing formic acid (11.43 mL, 298 mmol) and sulfuric acid (0.866 mL, 16.25 mmol), 2-amino-6-fluoro-4-methoxybenzonitrile (0.9 g 5.42 mmol). The reaction mixture was stirred at 100 °C for 1 h. Subsequently, it was cooled to room temperature and slowly poured into 80 mL of ice-water mixture. The resulting precipitate was collected by vacuum filtration and dried under vacuum to afford the target intermediate 5-fluoro-7-methoxy-4(3H)-one (0.8 g, 4.12 mmol) as an off-white solid.LC/MS (ESI+) analysis showed m/z = 195 ([M + H]+). | | References | [1] Patent: US2014/213581, 2014, A1. Location in patent: Paragraph 0635
[2] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 146
[3] Patent: US2015/38497, 2015, A1. Location in patent: Paragraph 0799
[4] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 319 |
| | 5-Fluoro-7-methoxyquinazolin-4(3H)-one Preparation Products And Raw materials |
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